Thyrotoxic neuropathy (Basedow's paraplegia).

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Thyrotoxic neuropathy (Basedow's paraplegia).

Polyneuropathy is a rare but possible manifestation of severe hyperthyroidism. The patient reported here developed a polyneuropathy affecting mostly leg muscles (Basedow's paraplegia) during the course of severe thyrotoxicosis. The polyneuropathy was confirmed with sequential electrophysiological studies of nerves and muscles and by muscle biopsy. The involvement of the proximal leg muscle is a...

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Thyrotoxic neuropathy- an under diagnosed condition.

Many neurological diseases like myopathy, periodic paralysis, ophthalmoplegia, and myasthenia gravis are known associations of thyrotoxicosis. However the association of neuropathy with thyrotoxicosis is not frequently recognized. First described by Charcot in 1889, thyrotoxic neuropathy or 'Basedow's Paraplegia' is a rarely reported entity. We describe here a case of a young woman with subacut...

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Sensory neuropathy in hereditary spastic paraplegia.

A large kinship is reported with dominantly inherited spastic paraplegia starting in the first decade of life; its clinical evolution was indistinguishable from that of "pure" hereditary spastic paraplegia (HSP). However, all patients studied had electrophysiological evidence of a predominantly sensory polyneuropathy, which was confirmed on nerve biopsy in three. The histological findings indic...

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Hereditary spastic paraplegia 3A associated with axonal neuropathy.

OBJECTIVE To study the frequency and distribution of mutations in SPG3A in a large cohort of patients with hereditary spastic paraplegia. DESIGN We screened a large cohort of 182 families and isolated cases with pure or complex hereditary spastic paraplegia phenotypes, which were negative for mutations in SPG4. RESULTS In 12 probands (6.6%), we identified 12 different SPG3A mutations (11 mi...

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[Thyrotoxic myopathy].

A variety of neuromuscular disorders has been described in adults in association with overactivity of the thyroid (Millikan and Haines, 1953; Ramsay, 1966; Engel, 1972). The most common of these disorders is a chronic myopathy, characterized by muscular atrophy and weakness involving predominantly proximal muscles (Adams and Rosman, 1971). The myopathic symptoms may precede the symptoms of thyr...

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ژورنال

عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry

سال: 1976

ISSN: 0022-3050

DOI: 10.1136/jnnp.39.5.491